PUMA, a Novel Proapoptotic Gene, Is Induced by p53
نویسندگان
چکیده
منابع مشابه
p53-upregulated modulator of apoptosis (PUMA): a novel proapoptotic molecule in the failing heart.
As the leading cause of mortality in the United States, heart failure (HF) represents a disease state affected by a complex interplay between genetic, physiological, and environmental factors. Understanding the molecular mechanisms underlying the progression from normal cardiac function to ventricular dysfunction and overt HF will facilitate the identification of new therapeutic targets. Specif...
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We identified a novel mouse gene, mRTVP-1, as a p53 target gene using differential display PCR and extensive promoter analysis. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 (hRTVP-1) protein by two short in-frame deletions of two and nine amino acids. RTVP-1 mRNA was induced in multiple cancer cell lines by adenovirus-mediated delivery of p53 and by gamma irradiatio...
متن کاملThe nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage.
The tumor suppressor p53 can induce apoptosis by activating gene expression in the nucleus, or by directly permeabilizing mitochondria in the cytoplasm. It has been shown that PUMA, a downstream target of p53 and a BH3-only Bcl-2 family member, plays an essential role in apoptosis induced by both nuclear and cytoplasmic p53. To understand how PUMA does so, we used homologous recombination to de...
متن کاملThe proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1.
The p53 tumor suppressor gene is believed to play an important role in neuronal cell death in acute neurological disease and in neurodegeneration. The p53 signaling cascade is complex, and the mechanism by which p53 induces apoptosis is cell type-dependent. Using DNA microarray analysis, we have found a striking induction of the proapoptotic gene, SIVA. SIVA is a proapoptotic protein containing...
متن کاملActivation of p53 and the pro-apoptotic p53 target gene PUMA during depolarization-induced apoptosis of chromaffin cells.
The pathogenesis of non-glutamatergic, depolarization-induced cell death is still enigmatic. Recently, we have shown that veratridine induces apoptosis in chromaffin cells, and we have demonstrated protective effects of antioxidants in this system, suggesting a role for Na+ channels and oxidative stress in depolarization-induced cell death. We examined the possible contribution of p53, a transc...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2001
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(01)00214-3